MSC Cruises will resume weekly voyages on the MSC Grandiosa from January 24.
The ship will leave every Sunday from the Italian port of Genoa and pick up passengers at other Italian ports. It will also stop at Valetta in Malta during the cruise.
The Italian operator was the first major cruise line in the world to resume sailing last August.
The cruises aren’t available to UK passengers, who are anyway banned from all non-essential travel, but MSC has started taking booking for its 2022 ex-Southampton cruises.