Loganair is set to suspend flights between City of Derry Airport and Manchester less than six months after the route started.
The airline says it will not operate the daily service between January and May 2020, although some flights will be available at Easter.
The airline has blamed the decision on low demand.
Commercial Director Kay Ryan said: “We apologise for inconvenience to anyone who has already booked travel during this seasonal stop in the service.
“Our forecasts indicate that bookings will be low over the post-New Year period, so we’ve taken the decision to take a break on the route from January 5 until May 21, with the exception of some flights at Easter.”
Customers who have already booked can get a full refund or transfer to a Manchester-Belfast International or Manchester-Belfast City flight.