Aer Lingus has formally applied to base a number of aircraft at Manchester Airport next year with a view to serving US routes.
It is expected that the carrier will seek to operate direct flights from Manchester to Chicago, New York, Orlando and Boston or Las Vegas.
The aircraft they are hoping to base at Manchester are believed to include three Airbus A320Neos and one Airbus A330 widebody.
Industry officials have said the move is part of synergies sought within the IAG group which owns Aer Lingus, British Airways and Iberia.
There is no indication so far the aircraft will be drawn from the fleet servicing scheduled routes from Irish airports.